Endocrine Abstracts

A 30 year old gentleman presented with long standing symptoms of polyuria and polydypsia and poor libido. On examination he was short (155 cm), weighed 108 kg with a body mass index of 45.1. Investigations revealed normal Blood Glucose, renal function, liver function and calcium. Water deprivation test confirmed the diagnosis of Cranial Diabetes Insipidus. He was started on DDAVP tablets 100 microgram’s twice daily. Further tests showed a normal IGF-1, synacthen test and ...

Background: Hyponatraemia is a frequently encountered problem in primary care. Management should be based on the cause as inappropriate treatment e.g. fluid restriction in patients with hypoadrenalism is dangerous and potentially life-threatening.Aims: We present five cases who presented with hyponatraemia in the primary care setting, to highlight diagnostic approach and implications for management.Case 1 - Hyponatraemia secondary ...

We present three cases of metastatic medullary thyroid carcinoma who developed severe Cushing’s syndrome from ectopic production of ACTH by the tumour. Following total thyroidectomy and external beam radiotherapy, the patients had remained symptom-free for 4, 9 and 25 years after initial presentation despite the presence of widespread hepatic metastases. However, with the onset of Cushing’s syndrome, patients became unwell with severe muscle weakness and lethargy. Me...